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sevoflurane + propofol (Ruijin Hospital)
- Development stage
- Unknown
- Lead developer
- Ruijin Hospital
- Modality
- Small Molecules
- Administration
- Inhalation, Intravenous
01
Overview
Sevoflurane + propofol refers to a combined anesthetic maintenance regimen evaluated by Ruijin Hospital for use in patients with coronary artery disease undergoing off-pump coronary artery bypass graft (OPCAB) surgery. This combination therapy utilizes sevoflurane, a volatile halogenated ether inhaled anesthetic, and propofol, a short-acting intravenous hypnotic agent. The primary objective of this specific clinical application was to evaluate the protective effects of the combination on circulating lymphocytes against surgery-induced apoptosis. Mechanistically, both agents modulate the GABA-A receptor, while sevoflurane also acts as an NMDA receptor antagonist. Clinical study results indicated that the combination regimen was superior to sevoflurane alone in protecting circulating lymphocytes from apoptosis, a process associated with the reduced expression of caspase-3 and apoptosis-inducing factor (AIF).
- Other names
- sevoflurane + propofol-Ruijin Hospital-coronary artery diseasecombine of sevoflurane and propofolsevoflurane-propofol combination
02
Targets
GABRR (GABA-A receptor subunit rho)NMDAR (Glutamate receptor ionotropic, NMDA)NaV (Voltage-gated sodium channels)
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