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sevoflurane + propofol-Signe Sloth Madsen
- Development stage
- Phase 4
- Lead developer
- Signe Sloth Madsen
- Modality
- Small Molecules
- Administration
- Inhalation, Intravenous
01
Overview
sevoflurane + propofol-Signe Sloth Madsen refers to a specific clinical research study, DANA1 (Neuroplasticity Induced by General Anaesthesia), conducted by Signe Sloth Madsen at Rigshospitalet, University of Copenhagen. This randomized, cross-over trial compares the neuroplastic effects of two standard general anesthetics: sevoflurane, an inhaled halogenated ether, and propofol, an intravenous sedative-hypnotic. Sevoflurane acts as a positive allosteric modulator of GABA-A and glycine receptors and an antagonist of NMDA receptors. Propofol primarily functions as a positive allosteric modulator of the GABA-A receptor. The study utilizes 3-T magnetic resonance imaging (MRI) to investigate de novo neuroplastic changes in healthy volunteers following a two-hour maintenance phase of anesthesia, exploring associations between neuroplastic changes, clinical outcomes, and biochemical markers.
- Other names
- Neuroplasticity Induced by General AnaesthesiaSevoflurane-propofol
02
Targets
GABRR (GABA-A receptor subunit rho)Glycine receptorGABRA2 (Gamma-aminobutyric acid receptor subunit alpha 2)NMDAR (Glutamate receptor ionotropic, NMDA)Nicotinic Acetylcholine Receptor
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