sevoflurane + tropisetron

sevoflurane + tropisetron (referred to as Group S+T in clinical trial NCT01304953) is a combination treatment regimen evaluated for the management of postoperative pain. Sevoflurane is an inhaled volatile anesthetic used for the induction and maintenance of general anesthesia, primarily acting as a positive allosteric modulator of GABA-A receptors and an antagonist of NMDA receptors. Tropisetron is a small molecule 5-hydroxytryptamine-3A (5-HT3A) receptor antagonist, traditionally used as an antiemetic (brand name Navoban). In research conducted by Huazhong University of Science and Technology, this combination was investigated for its potential to reduce early postoperative pain in women undergoing gynecological laparoscopy, with findings suggesting that tropisetron's analgesic effects are specifically associated with sevoflurane-based anesthesia.

Other names

Group S+T-Huazhong University of Science and Technology-postoperative painSevoflurane and TropisetronSevoflurane/Tropisetron