SH-DS01 + Metronidazole

SH-DS01 + metronidazole appears to be a combination therapy that includes metronidazole (an antibiotic) and SH-DS01 (likely a probiotic). The search results mention this combination being studied in women with unexplained infertility who are seeking IVF treatment[1]. ## Metronidazole Component Metronidazole is a well-established nitroimidazole antimicrobial that treats infections caused by bacteria and protozoa. It works by killing bacteria or other organisms causing infections[6]. It's commonly used for: - Trichomoniasis (except during first trimester of pregnancy)[2] - Bacterial vaginosis[2] - Amebiasis[2] - Various anaerobic infections (skin, abdomen, heart, reproductive organs, CNS, respiratory system)[2] - Infections by Bacteroides species, Clostridium, Fusobacterium, Peptococcus and Peptostreptococcus[2] - Topically for inflammatory lesions of rosacea[2] Metronidazole is available in various formulations including oral tablets, intravenous infusion, and topical applications. ## SH-DS01 Component The search results don't provide specific information about SH-DS01, but based on context, it appears to be a probiotic formulation being studied alongside metronidazole. The combination is being investigated in a clinical trial for women with unexplained infertility who are seeking IVF treatment[1]. ## Important Interactions and Precautions When using metronidazole (which is part of this combination): - Do not take with disulfiram within two weeks[6][7] - Avoid alcohol consumption during treatment and for 3 days after (can cause disulfiram-like reactions)[3][4] - Monitor carefully if taking with: - Warfarin or other blood thinners (increased bleeding risk)[3][6] - Lithium (potential toxicity)[3][6] - Busulfan (may require dose adjustments)[6] - Phenytoin or phenobarbital (may reduce metronidazole effectiveness)[6][8] The specific dosing, complete safety profile, and efficacy of the SH-DS01 + metronidazole combination would depend on the particular clinical context and study protocols being used.