Drug intelligence / Profile preview

SHR-4849 + SHR-1316 + SHR-8068 + BP102 + carboplatin + cisplatin

Development stage
Phase 2
Lead developer
Hengrui Therapeutics
Modality
Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous
01

Overview

This is a **combination regimen** consisting of six investigational and established antineoplastic agents: SHR-4849, SHR-1316, SHR-8068, BP102, carboplatin, and cisplatin. SHR-4849 is a novel antibody-drug conjugate (ADC) targeting **delta-like ligand 3 (DLL3)** with a **topoisomerase I (Topo-I) inhibitor** payload, currently in phase 1/2 clinical trials for advanced solid tumors including small cell lung cancer (SCLC) and neuroendocrine tumors (NETs)[1][3][4][7]. SHR-1316, SHR-8068, and BP102 are investigational compounds whose specific mechanisms are not disclosed in the provided context. Carboplatin and cisplatin are platinum-based chemotherapy agents widely used in oncology for their DNA crosslinking and cytotoxic effects. The combination aims to leverage targeted ADC therapy with established cytotoxic agents for enhanced antitumor efficacy in refractory or advanced solid malignancies.

02

Targets

CTLA-4 (Cytotoxic t-lymphocyte–associated protein 4)DLL3 (Delta-like ligand 3)DNACD274 (Programmed cell death protein 1 ligand 1)

Beyond the preview

Go deeper on SHR-4849 + SHR-1316 + SHR-8068 + BP102 + carboplatin + cisplatin.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on SHR-4849 + SHR-1316 + SHR-8068 + BP102 + carboplatin + cisplatin.

Gosset Free

Get started with Gosset.

Enter your corporate email.

Work email preferred.

Book a call