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Sihuang powder (Sihuang San) is a traditional Chinese medicine (TCM) topical formulation traditionally composed of four "yellow" herbs: *Rheum palmatum* (Da Huang), *Phellodendron amurense* (Huang Bai), *Scutellaria baicalensis* (Huang Qin), and *Coptis chinensis* (Huang Lian). It is primarily used for its anti-inflammatory, heat-clearing, and detoxifying properties. In clinical practice, it is often applied externally to treat localized inflammatory conditions such as infusion-induced phlebitis, skin infections, and soft tissue swelling. The powder is typically mixed with a liquid (such as honey, water, or vinegar) to form a paste for topical application. Recent clinical studies, such as those conducted by The Second Affiliated Hospital of Nanchang University, have explored its efficacy when combined with physical therapies like microwave irradiation to enhance absorption and therapeutic outcomes in phlebitis.
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