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sildenafil + tadalafil
- Development stage
- Unknown
- Lead developer
- Aspargo Laboratories
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination of sildenafil and tadalafil, two potent phosphodiesterase type 5 (PDE5) inhibitors, primarily indicated for the treatment of erectile dysfunction. Sildenafil provides a rapid onset of action, typically within 30 to 60 minutes, while tadalafil offers a significantly longer duration of effect, lasting up to 36 hours. This combination is frequently utilized in compounded formulations or specialized delivery formats such as chewable tablets and mints by telehealth providers. In clinical research conducted by Aspargo Labs, these combination products serve as reference comparators for evaluating the pharmacokinetic profile and bioavailability of proprietary liquid sildenafil suspensions like Hezkue (ASP-001) and Hezkue Turbo (ASP-001.1).
- Brand names
- Ro SparksHims Hard MintsBlueChewHello Cake ED Cake Meds
- Other names
- sildenafil and tadalafil combinationtadalafil + sildenafil
02
Targets
PDE6 (Phosphodiesterase 6)PDE11A (Phosphodiesterase 11A)PDE1 (Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase)PDE8A (Phosphodiesterase 8A)PDE3PDE5 (Phosphodiesterase 5A)
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