silk fibroin + chlorhexidine

Silk fibroin + chlorhexidine is a combination of silk fibroin, a natural protein polymer derived from silkworm cocoons, and chlorhexidine, a broad-spectrum antimicrobial agent. This combination is primarily used in the development of advanced wound dressings and drug delivery systems. Silk fibroin serves as a biocompatible scaffold or film that can be loaded with hydrophilic drugs like chlorhexidine to provide controlled release at the site of application[1][4]. The mechanism leverages the structural properties of silk fibroin for tissue regeneration and healing, while chlorhexidine provides local antimicrobial action to prevent infection[1][2][5]. The blend can be formulated as films or hydrogels for use in wound care, where it offers benefits such as enhanced mechanical strength, biocompatibility, biodegradability, and sustained drug release profiles[1][2][5]. Research indicates that loading with chlorhexidine does not significantly alter the physical properties of the silk fibroin film but enables effective antibacterial activity at wound sites[1].