Drug intelligence / Profile preview

silver nitrate + fluoride varnish

Development stage
Phase 1
Lead developer
Arwa Owais
Modality
Small Molecules
Administration
Topical
01

Overview

silver nitrate + fluoride varnish is a combination treatment protocol investigated for the non-invasive medical management of dental caries, particularly in the primary dentition of children. Developed and studied by Dr. Arwa Owais at the University of Iowa, the procedure involves the topical application of a silver nitrate solution to a carious lesion, followed by the application of fluoride varnish. Silver nitrate acts as a potent antimicrobial and sclerosing agent that arrests the progression of decay by denaturing proteins and killing cariogenic bacteria. The subsequent application of fluoride varnish serves to precipitate silver chloride, which helps to mask the potential for systemic absorption and reduces staining, while providing a high concentration of fluoride to promote the remineralization of the tooth structure and increase resistance to acid dissolution. This medical management strategy is intended as an alternative to traditional surgical restorations in pediatric patients.

Other names
Silver Nitrate for Caries in Primary Dentition protocol

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