Drug intelligence / Profile preview

simvastatin + atorvastatin + rosuvastatin + pravastatin

Development stage
Discontinued
Lead developer
Merck
Modality
Small Molecules
Administration
Oral
01

Overview

This is a combination of four statin drugs—simvastatin, atorvastatin, rosuvastatin, and pravastatin. Each is an HMG-CoA reductase inhibitor (statin) used to lower LDL cholesterol and reduce cardiovascular risk. Statins work by inhibiting the enzyme HMG-CoA reductase in the liver, which plays a central role in cholesterol biosynthesis. This leads to decreased cholesterol production and increased clearance of LDL from the bloodstream. While each statin has unique pharmacokinetic properties and potential for drug interactions, their primary mechanism is shared. There are no known approved pharmaceutical products that combine all four agents into a single formulation; such use would be highly unusual due to overlapping mechanisms and increased risk of adverse effects such as myopathy or rhabdomyolysis[2][8][10].

02

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)

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