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sinibolimab + lenvatinib
- Development stage
- Unknown
- Lead developer
- Eisai
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
Sinibolimab + lenvatinib is a combination therapy regimen being evaluated for the neoadjuvant treatment of locally advanced unresectable differentiated thyroid carcinoma. Sinibolimab is an anti-PD-1 monoclonal antibody that functions as an immune checkpoint inhibitor, enhancing the immune system's ability to detect and destroy tumor cells by blocking the interaction between PD-1 and its ligands. Lenvatinib is an oral multikinase inhibitor that targets vascular endothelial growth factor receptors (VEGFR1-3), fibroblast growth factor receptors (FGFR1-4), RET, KIT, and platelet-derived growth factor receptor alpha (PDGFRα), thereby providing anti-angiogenic and anti-proliferative effects. This combination is currently being studied in a Phase II clinical trial led by Zhejiang University to assess its efficacy in reducing tumor burden and making unresectable tumors eligible for surgical resection (R0/R1 resection).
- Other names
- Sinibolimab plus LenvatinibSinibolimab combined with LenvatinibImmunotherapy combined with Multikinase inhibitors in neoadjuvant treatment
02
Targets
FGFR4 (Fibroblast growth factor receptor 4)PDCD1 (Programmed cell death protein 1 receptor)KIT (c-KIT proto-oncogene receptor tyrosine kinase)VEGFR2 (Vascular endothelial growth factor receptor 2)FGFR3 (Fibroblast growth factor receptor 3)PDGFRA (Platelet-derived growth factor receptor alpha)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR3 (Vascular endothelial growth factor receptor 3)FGFR2 (Keratinocyte growth factor receptor)FGFR1 (Fibroblast growth factor receptor 1)RET (Rearranged during transfection receptor tyrosine kinase)
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