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sintilimab + pyrotinib
- Development stage
- Unknown
- Lead developer
- Innovent Biologics
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
**sintilimab + pyrotinib** is a combination therapy under clinical investigation, particularly for HER2-positive malignancies. **Sintilimab** is a fully human anti-programmed death 1 (PD-1) monoclonal antibody that blocks the PD-1/PD-L1 pathway, restoring T-cell activity for immune-mediated tumor killing. **Pyrotinib** is an oral, irreversible tyrosine kinase inhibitor that targets both human epidermal growth factor receptor 2 (HER2) and EGFR pathways, inhibiting cancer cell proliferation. The combination is being studied for synergistic anti-tumor efficacy in HER2-positive cancers, such as advanced breast cancer and non-small-cell lung cancer (NSCLC)[4][8]. Both agents are products of Chinese pharmaceutical innovation, with sintilimab developed by Innovent Biologics and Eli Lilly, and pyrotinib by Jiangsu Hengrui Medicine. Primary indications include HER2-positive breast cancer and HER2-mutated NSCLC.
- Other names
- sintilimab + pyrotinib
02
Targets
PDCD1 (Programmed cell death protein 1 receptor)EGFR T790M (Epidermal growth factor receptor T790M mutant)ERBB2 (Erb-b2 receptor tyrosine kinase 2)ERBB4 (Erb-b2 receptor tyrosine kinase 4)
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