sIPV + bOPV (Candy)

sIPV + bOPV (Candy) is a combination polio vaccine regimen that includes Sabin strain inactivated poliovirus vaccine (sIPV) and bivalent oral polio vaccine (bOPV). The sIPV component is an inactivated vaccine derived from attenuated Sabin poliovirus strains, designed to induce systemic immunity by stimulating the production of neutralizing antibodies against all three poliovirus serotypes. The bOPV component is a live-attenuated oral vaccine targeting poliovirus types 1 and 3, providing mucosal immunity in the gut to prevent virus transmission. This sequential or combined approach aims to maximize both humoral and mucosal immune responses for comprehensive protection against polio, supporting global eradication efforts. The "Candy" formulation likely refers to a child-friendly delivery format but specific details on this are not available in the provided sources. Clinical studies have shown that sequential administration of sIPV followed by bOPV achieves high seroconversion rates with good safety profiles[3][8]. This strategy is particularly relevant for countries transitioning from OPVs due to concerns about vaccine-derived polioviruses.

Other names

IPV + bOPVSabin IPV + bivalent OPV