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siraitia grosvenorii (The Affiliated Stomatological Hospital of GuangXi Medical University)
- Development stage
- Unknown
- Lead developer
- The Affiliated Stomatological Hospital of GuangXi Medical University
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Topical, Oral
01
Overview
*Siraitia grosvenorii*, commonly known as monk fruit or Luo Han Guo, is a perennial vine native to southern China and northern Thailand. In the context of dental medicine, it is being investigated as a natural anti-inflammatory and antioxidant adjunct for patients undergoing dental implant surgery, particularly those with chronic periodontitis. The extract is rich in mogrosides, which are glycosides that provide intense sweetness and exhibit bioactive properties, including the modulation of peri-implant microbiota and the reduction of inflammatory markers. The Affiliated Stomatological Hospital of GuangXi Medical University is evaluating its efficacy in improving soft tissue healing and alveolar bone changes following implant placement.
- Other names
- Monk fruitLuo Han GuoMomordica grosvenoriiSiraitia grosvenorii extract
02
Targets
TLR4 (Toll-like receptor 4)TNFA (Tumor necrosis factor alpha (soluble))NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)
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