sirolimus + ascorbic acid

This is a combination drug consisting of **sirolimus** (also known as rapamycin) and **ascorbic acid** (vitamin C), most notably used as a coating on drug-eluting stents such as D+Storm for **coronary artery disease**. Sirolimus functions as an mTOR inhibitor, exerting immunosuppressive and anti-proliferative effects by inhibiting T-lymphocyte activation and smooth muscle cell proliferation. Ascorbic acid is included for its role in promoting endothelial cell growth, reducing oxidative stress, and potentially lowering inflammation, which together may improve endothelialization and reduce restenosis following stent placement. The combination aims to balance the anti-proliferative effect of sirolimus (preventing neointimal hyperplasia) with the endothelial-supportive and antioxidative properties of ascorbic acid, to enhance vascular healing and stent safety[3][5].

Brand names

D+Storm