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siYW + LNP
- Development stage
- Preclinical
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
**siYW + LNP** is an investigational lipid-nanoparticle-formulated small interfering RNA therapy designed to simultaneously silence *YAP1* and *WWTR1*, which encode the Hippo-pathway transcriptional coactivators YAP and TAZ. In a CDAHFD mouse model of metabolic dysfunction-associated steatohepatitis with advanced liver fibrosis, systemic administration reduced hepatic *YAP1* and *WWTR1* expression, suppressed YAP/TAZ-responsive and profibrotic gene programs, and improved hepatic steatosis and fibrosis-related measures. The formulation remains a preclinical research-stage therapeutic approach without an assigned INN or marketed brand name.
- Other names
- siYW + LNPsiYW/LNP
02
Targets
TAZ (Transcriptional coactivator with PDZ-binding motif)YAP1 (YES-associated protein–transcriptional enhancer factor domain complex)
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