SLNP@CpG

**SLNP@CpG** is a preclinical, locally administered lipid-nanoparticle formulation that encapsulates immunostimulatory CpG oligodeoxynucleotides. The CpG cargo activates Toll-like receptor 9 in tumor-associated macrophages, increasing phagocytosis and tumor-antigen cross-presentation, repolarizing immunosuppressive M2-like macrophages toward an M1-like state, and remodeling the tumor microenvironment toward antitumor immunity. In murine E.G7-OVA and B16-F10 melanoma models, intratumoral administration suppressed tumor growth, prolonged survival, and generated durable antitumor immune memory. The formulation was developed at Korea Advanced Institute of Science and Technology.

Other names

CpG-encapsulating SLNPSLNP@CpG