sodium 1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol)

Sodium 1,2-dipalmitoyl-sn-glycero‑3‑phospho-(1′‑rac‑glycerol) (DPPG) is a synthetic phosphoglyceride and an anionic phospholipid. It consists of two palmitic acid (16:0) chains esterified to the sn‑glycerol backbone and a glycerophosphate head group. DPPG is widely used in pharmaceutical research as a key component for creating stable liposomes and lipid-based drug delivery systems due to its ability to impart negative charge and enhance membrane stability. It is also utilized in vaccine development as part of adjuvant formulations and in studies of biological membranes. In clinical settings, it serves as an excipient or functional ingredient in products such as ultrasound contrast agents (e.g., Lumason). Its mechanism of action relates primarily to its biophysical properties—stabilizing lipid bilayers rather than direct pharmacological activity[4][5][7].

Brand names

Lumason

Other names

1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol), sodium salt1,2-dipalmitoyl-sn-glycero-3-phosphorylglycerol sodium salt1,2-dihexadecanoyl-sn-glycero-3-phospho-(1′‑rac‑glycerol) sodium saltL‑α‑phosphatidyl-DL-glycerol, dipalmitoyl