sodium aescinate + dexamethasone

A combination therapy consisting of sodium aescinate, a triterpenoid saponin derived from horse chestnut seeds (Aesculus hippocastanum), and dexamethasone, a potent synthetic glucocorticoid. Sodium aescinate exerts anti-edematous and venotonic effects by reducing capillary permeability, inhibiting lysosomal enzymes such as hyaluronidase, and improving venous tone. Dexamethasone provides robust anti-inflammatory and immunosuppressive actions by acting as an agonist at the glucocorticoid receptor, thereby inhibiting the synthesis of pro-inflammatory cytokines and reducing leukocyte infiltration. This combination is primarily utilized in clinical settings, particularly in China, for the management of drug extravasation (e.g., chemotherapy-induced) to alleviate local pain, swelling, and tissue damage through topical application or local administration.

Other names

escin sodium + dexamethasoneaescin sodium + dexamethasonesodium aescinate + dexamethasone sodium phosphate