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Sodium bicarbonate + potassium chloride + sodium chloride + polyethylene glycol 3350 is an oral **osmotic laxative bowel preparation** used for colon cleansing before colonoscopy and other bowel examinations. The combination is a **small molecule** electrolyte-balanced polyethylene glycol formulation in which **polyethylene glycol 3350** acts as a nonabsorbable osmotic agent that retains water in the intestinal lumen, producing copious watery stool and mechanical cleansing of the colon, while **sodium chloride, sodium bicarbonate, and potassium chloride** help reduce net electrolyte disturbance during the purge. It is supplied as a **powder for oral solution** that is reconstituted with water, typically as a 4-liter preparation, and is marketed under brand names including **NuLYTELY** and **TriLyte**. The product is used in adults and in pediatric patients depending on labeling, and the original U.S. product was developed and commercialized as a prescription bowel preparation for pre-procedural cleansing.
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