Drug intelligence / Profile preview

sodium butyrate + probiotics

Development stage
Unknown
Lead developer
Nordic Biotic
Modality
Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Small Molecules, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration
Oral
01

Overview

A combination oral preparation containing **microencapsulated sodium butyrate** (a short-chain fatty acid) and a multi-strain **probiotic blend** composed of *Lactobacillus rhamnosus*, *Lactobacillus acidophilus*, *Bifidobacterium longum*, *Bifidobacterium bifidum*, and *Bifidobacterium lactis*. It is sometimes formulated with a small amount of the prebiotic short-chain fructooligosaccharide (scFOS), but the queried product focuses on the sodium butyrate and probiotic constituents. **Sodium butyrate** acts as an energy source for colonocytes, promotes intestinal barrier integrity, exhibits anti-inflammatory properties (involving inhibition of nuclear factor kappa B), and modulates pain and motility in the gastrointestinal tract. **Probiotics** in this formulation contribute to restoring healthy gut flora and aid in the production of endogenous SCFAs including butyrate. The combination is designed to relieve gastrointestinal symptoms, particularly in patients with irritable bowel syndrome (IBS), by addressing gut dysbiosis, improving mucosal integrity, and reducing inflammation[1][3][5].

02

Targets

FFAR2HDAC (HDAC family)

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