Drug intelligence / Profile preview

sodium chloride + calcium chloride + sodium lactate + magnesium chloride + dextrose

Development stage
Approved
Lead developer
Takeda
Modality
Small Molecules
Administration
Intraperitoneal
01

Overview

Sodium chloride + calcium chloride + sodium lactate + magnesium chloride + dextrose is a multi-electrolyte, dextrose-containing **peritoneal dialysis solution** used to manage renal failure during peritoneal dialysis. Dextrose creates an osmotic gradient across the peritoneal membrane, enabling ultrafiltration of excess water and removal of waste solutes; the electrolyte components support electrolyte balance, while lactate serves as a buffer that helps correct acid-base abnormalities. This composition is marketed in multiple product-specific formulations, including DIANEAL and DELFLEX products, with differing dextrose and calcium or magnesium concentrations. DIANEAL is indicated for acute or chronic renal failure, whereas DELFLEX is indicated for chronic kidney failure in patients maintained on peritoneal dialysis. ([accessdata.fda.gov](https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020183s024lbl.pdf))

Brand names
DELFLEXDELFLEX Low Magnesium Low CalciumDIANEALDIANEAL Low CalciumDIANEAL Low Calcium with DextroseDIANEAL PD-2DIANEAL PD-2 with Dextrose
Other names
dextrose + sodium chloride + sodium lactate + calcium chloride + magnesium chloridedextrose monohydrate + sodium chloride + sodium lactate + calcium chloride + magnesium chloridesodium chloride + sodium lactate + calcium chloride + magnesium chloride + dextrose

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