Drug intelligence / Profile preview

sodium chloride + furosemide

Development stage
Approved
Lead developer
Monash University
Modality
Small Molecules
Administration
Intravenous
01

Overview

This pharmacological intervention is a combination therapy used as an adjunct to extracorporeal shock wave lithotripsy (ESWL) for the treatment of kidney stones, specifically lower pole caliceal stones. The regimen consists of the intravenous administration of 0.5 liters of 0.9% sodium chloride (normal saline) and 20 mg of furosemide (also known as frusemide), a loop diuretic. Developed and studied by investigators at Monash University, this protocol is designed to induce forced diuresis. By increasing urinary flow and volume, the therapy aims to facilitate the mechanical flushing and gravitational clearance of stone fragments (gravel) from the renal calyces following shock wave fragmentation, particularly when combined with physical maneuvers such as inversion therapy.

Other names
hydration-Monash University-kidney stoneHydration with NaCl and frusemideNaCl + frusemideIV hydration and diuretic therapy
02

Targets

NKCC2 (Sodium-potassium-chloride cotransporter 2)

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