sodium chloride + sodium acetate

Sodium chloride + sodium acetate is a combination used in intravenous fluids for electrolyte replacement and correction of acid-base imbalances. Sodium chloride provides sodium and chloride ions essential for maintaining extracellular fluid volume and osmotic pressure. Sodium acetate serves as a bicarbonate precursor, metabolizing to bicarbonate in the liver to help correct metabolic acidosis. This combination is particularly useful in preventing hyperchloremia while providing necessary sodium replacement[1][3]. The combination is commonly used in balanced crystalloid solutions like Normosol-R, where it's combined with other electrolytes to create a physiologically balanced solution. These solutions are indicated for replacement of acute extracellular fluid volume losses in surgery, trauma, burns, or shock[2][7].

Brand names

Normosol-RPhysioSol