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Sodium chlorure 0,9 % (0.9% sodium chloride solution, commonly known as normal saline) is a sterile, isotonic, small-molecule inorganic salt solution. It is widely used in clinical settings for intravenous fluid and electrolyte replenishment, as well as a vehicle or placebo comparator in clinical trials. In a Phase 3 randomized, double-blind, placebo-controlled trial (NCT01690585) sponsored by University Hospital, Rouen, it was utilized as the intravenous placebo control to evaluate the efficacy of ferric carboxymaltose (Ferinject) in correcting anemia in elderly patients following acute gastrointestinal bleeding. As a physiologically inert solution, it does not have a specific biological target or active therapeutic effect on anemia, but serves to maintain fluid balance and provide a baseline comparator for active treatments.
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