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Sodium chloride 0.9% (normal saline) is an isotonic inorganic salt solution. In the Phase 2 clinical trial NCT03238625 conducted by the University of Zurich, it was utilized as a placebo comparator (IMP4) to evaluate pain during local anesthetic infiltration of lidocaine/epinephrine buffered with sodium bicarbonate. As a placebo, it contains no active anesthetic ingredients, has no specific biological targets, and possesses no therapeutic indication in this context.
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