Drug intelligence / Profile preview

sodium fluoride + sodium bicarbonate

Development stage
Unknown
Lead developer
Colgate-Palmolive
Modality
Small Molecules
Administration
Oral (topical, As In Toothpaste)
01

Overview

**Sodium fluoride + sodium bicarbonate** is a combination of two inorganic compounds often used as active ingredients in dentifrices (toothpastes). Sodium fluoride acts as an anti-caries agent by promoting remineralization of tooth enamel and inhibiting the demineralization process, as well as inhibiting bacterial enzymes that contribute to caries formation. Sodium bicarbonate functions primarily as a buffering and cleaning agent, neutralizing plaque acids and raising oral pH, thereby aiding in the reduction of dental plaque and improving gum health. These effects are complementary, with sodium fluoride strengthening enamel and sodium bicarbonate facilitating plaque removal and maintaining a neutral oral environment by acting as a mild abrasive and alkaline agent[2][3][4][6][8].

Brand names
Arm & Hammer Dental CareArm & Hammer Advance WhiteArm & Hammer Complete CareArm & Hammer Enamel Pro
Other names
sodium fluoride and baking soda toothpaste

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