Drug intelligence / Profile preview

sodium gluconate + potassium chloride + sodium acetate + magnesium chloride + sodium chloride

Development stage
Unknown
Lead developer
Takeda
Modality
Small Molecules
Administration
Intravenous
01

Overview

A sterile, nonpyrogenic, isotonic **multiple-electrolyte intravenous solution** containing sodium gluconate, potassium chloride, sodium acetate, magnesium chloride, and sodium chloride, marketed most commonly as **Plasma-Lyte A** and **Plasma-Lyte 148**. It is used in adults and pediatric patients as a source of water and electrolytes for hydration, for correction of dehydration and electrolyte disturbances, and as an alkalinizing agent. Its pharmacologic effect is replacement of extracellular fluid electrolytes together with support of **acid-base homeostasis**; acetate and gluconate are metabolized to bicarbonate precursors and thereby help buffer metabolic acidosis. This product is an approved pharmaceutical combination of inorganic salts rather than a biologic, oncology asset, or antimicrobial drug. A related electrolyte irrigating solution exists, but the injectable drug of interest here is the balanced IV crystalloid formulation.

Brand names
Plasma-Lyte APlasma-Lyte 148Plasma-Lyte148Plasma-Lyte-148
Other names
Multiple Electrolytes Injection Type 1multiple electrolytes injection type 1 uspsodium gluconate + potassium chloride + sodium acetate + magnesium chloride + sodium chloride

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