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sodium hyaluronate + hydrocortisone sodium phosphate
- Development stage
- Unknown
- Lead developer
- Alfa Intes
- Modality
- Implantable Devices → Device-based Delivery → Drug Delivery Systems, Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
- Administration
- Ophthalmic
01
Overview
This is a fixed-dose combination ophthalmic formulation containing sodium hyaluronate (also known as hyaluronic acid) and hydrocortisone sodium phosphate. Sodium hyaluronate is a naturally occurring glycosaminoglycan with viscoelastic and lubricating properties, commonly used to hydrate and protect the ocular surface. Hydrocortisone sodium phosphate is a synthetic glucocorticoid corticosteroid that exerts anti-inflammatory effects by suppressing inflammatory cytokines and immune cell activity. The combination aims to synergize the moisturizing effect of hyaluronic acid with the mild anti-inflammatory action of low-dose hydrocortisone, providing relief for dry eye disease (DED) by improving tear film stability, reducing para-inflammation on the ocular surface, and alleviating symptoms associated with meibomian gland dysfunction[1][3]. Clinical studies have shown this combination improves both objective signs (tear film stability) and subjective symptoms in DED patients[1][3].
- Brand names
- IdroflogHAC eyedrops
- Other names
- sodium hyaluronate and hydrocortisone sodium phosphatehyaluronic acid + hydrocortisone sodium phosphate
02
Targets
GR (Glucocorticoid receptor)
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