Drug intelligence / Profile preview

sodium phosphate, monobasic, monohydrate + sodium phosphate, dibasic, anhydrous

Development stage
Unknown
Lead developer
Salix Pharmaceuticals
Modality
Small Molecules
Administration
Oral, Intravenous
01

Overview

Sodium phosphate, monobasic, monohydrate + sodium phosphate, dibasic, anhydrous is a **combination of two inorganic phosphate salts** used in both oral and intravenous pharmaceutical products. In the oral tablet product **Visicol**, it acts as an **osmotic laxative/purgative** for bowel cleansing before colonoscopy by drawing water into the intestinal lumen and promoting rapid evacuation. In intravenous products marketed as **sodium phosphates injection**, the same salt pair serves as a **parenteral phosphorus replacement** to prevent or correct hypophosphatemia in patients with inadequate oral intake. The combination provides systemic phosphate and sodium rather than acting through a discrete receptor target, and its pharmacology relates to phosphate homeostasis, osmotic fluid shifts, acid-base buffering, and cellular metabolic needs. Oral sodium phosphate products carry a boxed warning for **acute phosphate nephropathy** and require careful hydration and avoidance in at-risk patients.

Brand names
Visicol
Other names
monobasic sodium phosphate and dibasic sodium phosphate tabletssodium phosphates injectionsodium phosphate monobasic monohydrate + sodium phosphate dibasic anhydrous

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