sodium sulfate + magnesium sulfate + potassium sulfate (Peking Union Medical College Hospital)

Oral sulphate solution (OSS) is an osmotic laxative formulation used for bowel cleansing prior to colonoscopy or other medical procedures requiring a clear colon. It typically consists of a combination of sodium sulfate, potassium sulfate, and magnesium sulfate. The solution works by creating an osmotic gradient in the intestinal tract, which prevents the absorption of water and promotes the accumulation of fluid in the bowel lumen. This increased volume stimulates peristalsis and leads to effective evacuation of the colon. OSS is noted for its high efficacy in bowel preparation, often achieving superior cleansing compared to traditional polyethylene glycol (PEG) solutions, and is associated with high patient adherence due to its relatively low volume requirements. In China, it is evaluated in real-world practice for colorectal neoplasm screening indications.

Brand names

SuprepSuClearYijiewei

Other names

oral sulphate solutionOSSsulphate solutioncompound sodium sulfate oral solutionsodium sulfate, potassium sulfate, and magnesium sulfate oral solution