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sofosbuvir + glecaprevir + pibrentasvir
- Development stage
- Phase 4
- Lead developer
- AbbVie
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination antiviral therapy consisting of sofosbuvir (an HCV NS5B polymerase inhibitor), glecaprevir (an HCV NS3/4A protease inhibitor), and pibrentasvir (an HCV NS5A inhibitor). This triple combination is used primarily for treating hepatitis C virus (HCV) infection in patients who have failed previous direct-acting antiviral therapies, including post-liver transplant patients with recurrent HCV infection. The combination targets three different viral proteins simultaneously, providing a high barrier to resistance and effectiveness against multiple HCV genotypes.
02
Targets
NS3/4A (Hepatitis C virus nonstructural protein 3/4A serine protease)NS5A (Hepatitis C virus nonstructural protein 5A (genotype 1b))NS5B (Hepatitis C virus non-structural protein 5B (NS5B) RNA-dependent RNA polymerase)
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