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somatropin + clonidine + l-arginine hydrochloride + estradiol valerate
- Development stage
- Unknown
- Lead developer
- Goethe University Hospital
- Modality
- Recombinant Proteins and Enzymes, Peptides, Small Molecules
- Administration
- Subcutaneous, Oral, Intravenous
01
Overview
This combination refers to a clinical protocol used to evaluate and manage growth failure in children with Ataxia Telangiectasia (A-T). It consists of somatropin, a recombinant human growth hormone (rhGH) used for replacement therapy, alongside three diagnostic agents: clonidine, l-arginine hydrochloride, and estradiol valerate. Clonidine, an alpha-2 adrenergic agonist, and l-arginine, an amino acid that inhibits somatostatin release, are used as provocative agents in growth hormone stimulation tests to trigger endogenous GH secretion from the pituitary gland. Estradiol valerate is utilized for hormonal priming to enhance the sensitivity and diagnostic accuracy of these tests in peripubertal children. The protocol is primarily associated with research at the Johann Wolfgang Goethe University Hospital aimed at characterizing the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis in A-T patients, who frequently exhibit significant growth retardation.
- Other names
- somatropin + clonidine + l-arginin-hydrochloride + estradiol valerate
02
Targets
GHR (Growth hormone receptor)ADRA2A (α2A)SST (Somatostatin)ESR1 (ERα)
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