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sophora granules (Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine)
- Development stage
- Unknown
- Lead developer
- Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Sophora granules are a Traditional Chinese Medicine (TCM) preparation derived from the root of *Sophora flavescens* (Kushen). In oncology, it is primarily utilized as an adjuvant therapy to improve prognosis and reduce adverse reactions to chemotherapy in patients with various malignancies, including triple-negative breast cancer (TNBC). The granules are hypothesized to exert anticancer effects by modulating the immune microenvironment, specifically by enhancing the activity of CD8+ T cells, and by inhibiting the mTOR (mammalian target of rapamycin) signaling pathway. It is currently being investigated in clinical trials for its efficacy in post-operative TNBC patients to prolong survival and explore its mechanism of action on human CD8+ and mTOR targets.
- Other names
- Kushen granulesSophora flavescens granulesKu Shen Ke Li
02
Targets
CHRNA9 (nAChR α9 subunit)VEGFR2 (Vascular endothelial growth factor receptor 2)CD8A (CD8 alpha/beta Coreceptor)ESRRG (Estrogen-related receptor gamma)FZD7 (Frizzled class receptor 7)mTOR (Mammalian target of rapamycin kinase)
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