Drug intelligence / Profile preview

sotagliflozin + norgestimate + ethinyl estradiol

Development stage
Unknown
Lead developer
Lexicon Pharmaceuticals
Modality
Small Molecules
Administration
Oral
01

Overview

This is a combination drug containing **sotagliflozin**, a dual sodium-glucose co-transporter 1 and 2 (SGLT1/2) inhibitor used primarily for diabetes management, and **norgestimate + ethinyl estradiol**, which is a well-established oral contraceptive combination used for birth control and treating acne in women. - **Sotagliflozin** lowers blood glucose by inhibiting SGLT1 in the gut and SGLT2 in the kidney, reducing glucose reabsorption and increasing urinary glucose excretion. - **Norgestimate** is a progestin and **ethinyl estradiol** is an estrogen; together, they suppress ovulation, alter cervical mucus and endometrial lining, preventing pregnancy[1][2][3].

02

Targets

SLC5A1 (Sodium Glucose Cotransporter 1)PR (Progesterone receptor)SGLT2 (Sodium-glucose cotransporter protein subunit 2)ER (Estrogen receptor)

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