Drug intelligence / Profile preview

sotatercept + prednisone

Development stage
Unknown
Lead developer
Merck
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Subcutaneous, Oral
01

Overview

Sotatercept + prednisone is a combination of two drugs used in clinical settings. Sotatercept is a first-in-class biologic agent that acts as an activin signaling inhibitor targeting the bone morphogenetic protein/activin pathway. It is primarily indicated for the treatment of pulmonary arterial hypertension (PAH), where it improves exercise capacity and reduces clinical worsening when added to background therapy[3][4][6]. Sotatercept was developed by Merck and is marketed under the brand name WINREVAIR[3][7]. Prednisone is a synthetic glucocorticoid corticosteroid with potent anti-inflammatory and immunosuppressive properties, widely used for various inflammatory and autoimmune conditions. The combination may be considered in specific clinical scenarios where both agents are indicated; however, there are no major studies or approvals specifically for their combined use as a fixed-dose product.

Other names
sotatercept and prednisone
02

Targets

GDF8 (Myostatin)GR (Glucocorticoid receptor)

Beyond the preview

Go deeper on sotatercept + prednisone.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on sotatercept + prednisone.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call