Drug intelligence / Profile preview

soy isoflavones + magnolia extract

Development stage
Unknown
Lead developer
Viatris
Modality
Small Molecules
Administration
Oral
01

Overview

A combination nutraceutical containing **soy isoflavones** and **magnolia extract** is used primarily to alleviate vasomotor and psychoaffective symptoms in postmenopausal women. *Soy isoflavones* are phytoestrogens that can bind and modulate estrogen receptors, reducing the severity and frequency of hot flushes, night sweats, sleep disturbances, mood swings, and other menopausal symptoms. *Magnolia extract* (from Magnolia officinalis) contains biologically active compounds such as magnolol and honokiol, which exert anxiolytic, neurotrophic, and anti-inflammatory effects, likely through modulation of GABA-A receptors and enhancement of melatonin secretion. This combination is intended to synergize the estrogenic effects of isoflavones with the calming and sleep-promoting properties of magnolia, improving overall quality of life in postmenopausal women. Clinical studies indicate the combination is effective and well-tolerated, without adverse effects on mammary density, endometrial thickness, or liver function over 12 months[1][3][5][7].

02

Targets

ESRRG (Estrogen-related receptor gamma)GABRR (GABA-A receptor subunit rho)ESR1 (ERα)PPAR (PPAR family)ESR2 (ERβ)THR (Thyroid hormone receptor)

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