Drug intelligence / Profile preview

spironolactone + adalimumab + infliximab + ertapenem + finasteride + triamcinolone + oral antibiotics + birth control

Development stage
Unknown
Lead developer
Pfizer
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Oral, Subcutaneous, Intravenous, Intramuscular, Intralesional, Topical
01

Overview

This combination refers to a set of core therapies utilized in the management of **Hidradenitis Suppurativa (HS)**, as identified in clinical research evaluating the impact of Polycystic Ovary Syndrome (PCOS) on HS severity. The regimen includes anti-androgens (**spironolactone**, **finasteride**), biologic TNF-alpha inhibitors (**adalimumab**, **infliximab**), corticosteroids (**triamcinolone**), and various antimicrobial agents (**ertapenem**, **oral antibiotics**), alongside hormonal **birth control**. These treatments aim to address the inflammatory, hormonal, and bacterial components of HS pathogenesis. Adalimumab is currently the only FDA-approved biologic for HS, while the other components are frequently used off-label or as standard-of-care supportive therapies.

02

Targets

MR (Mineralocorticoid receptor)SRD5A2 (Steroid 5-alpha-reductase type II)ER (Estrogen receptor)TNFA (Tumor necrosis factor alpha (soluble))PBP (Penicillin-binding protein family)GR (Glucocorticoid receptor)PR (Progesterone receptor)AR (Adrenergic receptors)

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