spironolactone + vitamin e

Spironolactone + vitamin E is a combination therapy consisting of the potassium-sparing diuretic spironolactone and the antioxidant vitamin E. This combination has been studied primarily for its effects in patients with non-alcoholic fatty liver disease (NAFLD). Spironolactone acts as a mineralocorticoid receptor antagonist, reducing sodium reabsorption and potassium excretion, while also exhibiting anti-androgenic properties. Vitamin E is an antioxidant that helps protect cells from oxidative damage. Clinical studies have shown that low-dose spironolactone combined with vitamin E can significantly decrease liver fat scores and improve insulin resistance in NAFLD patients compared to vitamin E alone[1][2][3][5]. The regimen may offer metabolic benefits but requires further large-scale trials to confirm efficacy and safety.