Drug intelligence / Profile preview

SRP + boric acid

Development stage
Preclinical
Modality
Small Molecules
Administration
Subgingival, Topical
01

Overview

SRP + boric acid refers to the combination therapy of scaling and root planing (SRP), a standard non-surgical periodontal treatment, with adjunctive local application of boric acid. This combination is used in the management of periodontitis. Boric acid is applied either as a gel or via irrigation after mechanical debridement (SRP). The rationale for this approach is that while SRP removes dental plaque and calculus mechanically, the addition of boric acid provides antimicrobial effects—boric acid exhibits fungistatic and weak bacteriostatic properties, inhibits biofilm formation, hyphal transformation in fungi such as Candida albicans, and may reduce pathogenic bacteria associated with periodontitis[1][2][3][6]. Clinical studies have shown that adjunctive use of boric acid with SRP can lead to greater improvements in periodontal parameters such as probing pocket depth (PPD) reduction and clinical attachment level (CAL) gain compared to SRP alone or placebo[1][3]. The mechanism by which this occurs likely involves both direct antimicrobial action on subgingival pathogens and inhibition of biofilm formation.

Other names
SRP plus boric acidscaling and root planing with boric acidSRP and boric acid

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