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St. Jude Children's Research Hospital PXR compound 85
- Development stage
- Unknown
- Lead developer
- St. Jude Children's Research Hospital
01
Overview
St. Jude Children's Research Hospital PXR compound 85: sourced facts only. name: "Herein, we report the structural optimization of a series of 1H-1,2,3-triazole-4-carboxamides compounds that led to the discovery of compound 85 as a selective and the most potent inverse agonist and antagonist of PXR, with low nanomolar IC50 values for binding and cellular activity." [PMID:36480704]; target: "Herein, we report the structural optimization of a series of 1H-1,2,3-triazole-4-carboxamides compounds that led to the discovery of compound 85 as a selective and the most potent inverse agonist and antagonist of PXR, with low nanomolar IC50 values for binding and cellular activity." [PMID:36480704]; developer: "Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States." [PMID:36480704]
02
Targets
PXR (Pregnane X receptor)
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