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Standard multimodal pain management regimen (Bradbury)
- Development stage
- Unknown
- Lead developer
- Thomas L Bradbury
- Modality
- Small Molecules
- Administration
- Intravenous, Oral, Topical
01
Overview
The standard multimodal pain management regimen (Bradbury) is a specific perioperative analgesic protocol utilized in clinical trials led by Thomas L. Bradbury, particularly for patients undergoing total knee arthroplasty (TKA). The regimen is designed to optimize pain control and reduce opioid consumption by targeting multiple pain pathways. It includes preoperative administration of intravenous dexamethasone (Decadron), intraoperative local infiltration with ropivacaine and intravenous ketorolac (Toradol), and a postoperative schedule of acetaminophen (Tylenol) combined with as-needed opioids such as oxycodone, morphine, or hydromorphone (Dilaudid). This multimodal approach aims to improve postoperative outcomes and patient recovery by providing comprehensive analgesia and managing inflammation associated with major orthopedic surgery.
- Other names
- Standard multimodal pain management regimenStandard multimodal postoperative pain management regimen
02
Targets
PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)MOR (Mu opioid receptor)GR (Glucocorticoid receptor)NaV (Voltage-gated sodium channels)
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