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Drug intelligence / Profile preview
stannous fluoride + nitrate + pyrophosphate
- Development stage
- Unknown
- Lead developer
- Colgate-Palmolive
- Modality
- Small Molecules
- Administration
- Topical (oral, As Toothpaste)
01
Overview
**Stannous fluoride + nitrate + pyrophosphate** is an oral care combination drug and technology found in advanced toothpaste formulations, sometimes referred to as SNaP technology. It is designed to enhance the stability and efficacy of stannous fluoride for oral health use. **Stannous fluoride** acts via anti-caries, antimicrobial, antiplaque, and anti-hypersensitivity effects, reducing viability of oral biofilm, remineralizing tooth mineral, and forming a protective barrier on dentin. **Nitrate** (typically as potassium nitrate) is included for its desensitizing properties, reducing dental hypersensitivity by calming nerve responses in dentin. **Pyrophosphate** serves mainly as a stabilizer to prevent precipitation and degradation of stannous ions, and may also help inhibit calculus (tartar) formation. This combination has demonstrated statistically significant clinical benefit in reducing plaque, gingivitis, hypersensitivity, and oral malodor compared to regular fluoride products.
- Brand names
- Colgate Total SFColgate Total
- Other names
- SNaP toothpaste
02
Targets
Gtf (Streptococcus mutans glucosyltransferase)ASP (Acquired salivary pellicle proteins)
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