steroids + immunosuppressive agents + intravenous immunoglobulin

This is a combination therapy consisting of corticosteroids (such as prednisolone or methylprednisolone), immunosuppressive agents (such as tacrolimus), and intravenous immunoglobulin (IVIG). The regimen is used primarily for the treatment of severe, refractory, or immune-mediated diseases where monotherapy has failed or rapid disease control is needed. Mechanistically, corticosteroids suppress inflammation and modulate immune responses by inhibiting multiple inflammatory pathways; immunosuppressive agents further dampen the immune system by targeting specific cellular processes; IVIG provides passive immunity and modulates autoantibody activity through multiple mechanisms including Fc receptor blockade and anti-inflammatory effects. This combination has been studied in conditions such as chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), immune-mediated necrotizing myopathy (IMNM), sporadic inclusion body myositis, and pemphigus vulgaris[1][2][3][4].