strep A vaccine + alum

A Strep A vaccine formulated with an aluminum-based adjuvant (alum) is a therapeutic candidate designed to prevent infections caused by *Streptococcus pyogenes* (Group A Streptococcus). These vaccines typically employ protein subunit or peptide-based platforms, targeting the highly variable M protein or more conserved surface antigens to elicit protective neutralizing antibodies. The addition of alum (aluminum hydroxide or aluminum phosphate) serves to enhance the magnitude and duration of the immune response by creating a depot effect and stimulating pro-inflammatory pathways. Several such candidates have reached clinical trials, including multivalent M protein vaccines (such as the 30-valent StreptAnova) and conserved peptide conjugates (such as J8-DT and MJ8), aiming to address the global burden of GAS-related diseases such as pharyngitis, impetigo, and life-threatening sequelae like rheumatic heart disease.

Other names

Group A Streptococcus vaccine with aluminum adjuvantGAS vaccine + alumstrep A vaccine + aluminum hydroxidestrep A vaccine + aluminum phosphate