Drug intelligence / Profile preview

sucralfate + oxetacaine + simethicone

Development stage
Unknown
Lead developer
Laksun Lifesciences
Modality
Small Molecules
Administration
Oral
01

Overview

Sucralfate + oxetacaine + simethicone is a fixed-dose combination oral suspension used for the management of gastrointestinal disorders including peptic ulcers, gastritis, and gastroesophageal reflux disease (GERD) associated with flatulence. **Sucralfate** acts as a cytoprotective agent by adhering to ulcer sites and forming a protective proteinaceous barrier against acid, pepsin, and bile salts. **Oxetacaine** (also known as oxethazaine) is a potent local anesthetic that provides rapid symptomatic relief from pain by numbing the esophageal and gastric mucosa; it is unique for maintaining its anesthetic activity even in highly acidic environments. **Simethicone** serves as an anti-foaming agent that reduces the surface tension of gas bubbles in the digestive tract, facilitating their coalescence and expulsion to relieve bloating and gas-related discomfort. This combination is primarily marketed in India by companies such as Laksun Lifesciences.

Other names
Sucralfate Oxetacaine Simethicone Syrupsucralfate + oxethazaine + simethicone
02

Targets

FGF (Fibroblast growth factor 6)Gas bubble and foam interface in gastrointestinal contentsGastric and duodenal mucosal mucin and proteinaceous exudateNaV (Voltage-gated sodium channels)PEP (Pepsin)

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