sufentanil + dexmedetomidine + flurbiprofen

This is a combination of three drugs—sufentanil, dexmedetomidine, and flurbiprofen (often as the axetil formulation)—used primarily for multimodal analgesia in perioperative and postoperative settings. - **Sufentanil** is a potent synthetic opioid analgesic that acts mainly as a μ-opioid receptor agonist, providing strong pain relief and sedation[4][5]. - **Dexmedetomidine** is an alpha-2 adrenergic receptor agonist with sedative, anxiolytic, and analgesic properties; it reduces sympathetic tone and can decrease opioid requirements[2][3]. - **Flurbiprofen** (commonly administered as flurbiprofen axetil) is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes (COX-1/COX-2), reducing prostaglandin synthesis to provide anti-inflammatory and analgesic effects[2][6]. The combination leverages synergistic mechanisms to enhance pain control while minimizing opioid consumption. It has been studied for use in patient-controlled intravenous analgesia (PCIA) after major surgeries such as gastrointestinal tumor resection or laparoscopic procedures. Clinical studies indicate this regimen improves postoperative pain scores compared to opioids alone or other regimens, reduces hyperalgesia risk, lowers total opioid consumption, may improve recovery quality, and can reduce some adverse effects associated with high-dose opioids[1][2][5].

Other names

sufentanil + dexmedetomidine + flurbiprofen axetil