Drug intelligence / Profile preview

sulfaguanidine + phthalylsulfathiazole + streptomycin + activated charcoal

Development stage
Phase 3
Lead developer
Albert Schatz
Modality
Small Molecules
Administration
Oral
01

Overview

This is a combination drug containing four active ingredients: - **Sulfaguanidine** is a sulfonamide antibacterial agent primarily used to treat gastrointestinal infections caused by bacteria. It acts as a bacteriostatic agent by inhibiting folic acid synthesis in susceptible microorganisms, thereby interfering with nucleic acid synthesis[1][2][3][5]. - **Phthalylsulfathiazole** is another sulfonamide antibiotic, also used for intestinal infections due to its poor absorption from the gut, allowing it to act locally. - **Streptomycin** is an aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, leading to cell death. It has activity against various Gram-negative and some Gram-positive bacteria. - **Activated charcoal** is an adsorbent used medically for gastrointestinal decontamination in cases of poisoning or overdose and sometimes as adjunctive therapy for diarrhea. It works by adsorbing toxins and drugs in the GI tract, preventing their absorption[6][8][10]. This combination targets enteric (intestinal) bacterial infections and may be formulated for use in acute diarrheal illnesses where both antimicrobial action (from the antibiotics) and toxin/drug adsorption (from activated charcoal) are desired.

02

Targets

Bacterial RibosomeDHPS (Dihydropteroate synthase)

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