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sulfated rhamnose polysaccharides chromium(III) complex
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Sulfated rhamnose polysaccharides chromium(III) complex (SRPC) is a novel research-stage bioactive coordination compound synthesized by chelating sulfated rhamnose polysaccharides—extracted from the green alga *Enteromorpha prolifera*—with chromium(III) ions. It is primarily investigated for its potential in treating type 2 diabetes mellitus (T2DM), where it has demonstrated significant hypoglycemic and hypolipidemic effects in preclinical mouse models. SRPC works by activating the insulin signaling pathway, specifically the IR/IRS-2/PI3K/PKB/GSK-3β axis, which enhances glycogen synthesis and promotes the translocation of glucose transporter 4 (GLUT4) in skeletal muscle to improve glucose uptake. Preclinical data indicate that oral administration of SRPC can improve glucose tolerance, reduce body mass gain, and lower serum insulin levels.
- Other names
- sulfated rhamnose polysaccharides chromium(III) complexSRPC
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)INSR (Insulin receptor)GSK3 (Glycogen synthase kinase 3 beta)SLC2A4 (Solute carrier family 2 facilitated glucose transporter member 4)IRS2 (Insulin receptor substrate 2)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)
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