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sulfur hexafluoride + tissue plasminogen activator
- Development stage
- Unknown
- Lead developer
- Bracco
- Modality
- Small Molecules, Recombinant Proteins and Enzymes
- Administration
- Intravenous, Intracatheter
01
Overview
This is a combination of two agents, sulfur hexafluoride and tissue plasminogen activator (tPA). Sulfur hexafluoride is an inert gas commonly used as a contrast agent in ultrasound imaging. Tissue plasminogen activator is a serine protease enzyme that catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for clot breakdown. tPA is used clinically as a thrombolytic drug to dissolve blood clots in conditions such as acute ischemic stroke, myocardial infarction, and massive pulmonary embolism[2][3][4]. The combination may be under investigation for enhanced thrombolysis or targeted delivery applications; however, there are no approved pharmaceutical products combining these two agents.
- Other names
- tPA + SF6rt-PA + SF6
02
Targets
Fibrin (Factor Ia)PLG (Plasminogen)
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